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For oral steroid therapy, patients received 60 milligrams of prednisone for 14 days, followed by a tapering-off period of 5 days. Subjects were asked to return promptly for followup measurements. Results: The baseline values of blood levels of total testosterone (T/T) increased significantly (Figure ), while the level of DHT (DHT/T) decreased significantly for both groups. There was no significant difference in the percent decrease in blood levels of testosterone for the two treatments: a decline of 4.4% for patients taking prednisone and 6.3% for those taking placebo. Serum T/T declined, whereas T/DHT decreased significantly. There was no significant difference in change of DHT between treatments: a decline of 0.5% for patients taking prednisone and 4.4% for those taking placebo. Conclusion: The increase in T/T and decrease in DHT were not associated with any adverse effects associated with the treatment of TSH suppression (P > 0.05) and there was no significant change in serum levels of FSH, LH, E2 and free T from the treatment. Similar articles: